Q.1 Which one of the followings is used as a mood stabilizer for bipolar disorder and also in certain epileptic convulsions?
(A) Phenytoin
(B) Lithium
(C) Sodium valproate
(D) Fluoxetine
Option C

Q.2 An isosteric replacement for carboxylic acid group is
(A) pyrrole
(B) isoxazole
(C) phenol
(D) tetrazole
Option D
Q.3 The given antibiotic is an example of ansamycins:
(A) Roxythromycin
(B) Adriamycin
(C) Aureomycin
(D) Rifamycin
Option D

Q.4 For glyburide, all of the following metabolic reactions are logical except
(A) O-demethylation
(B) aromatic oxidation
(C) benzylic hydroxylation
(D) amide hydrolysis
Option B

Q.5 The effects observed following systemic administration of levodopa in the treatment of Parkinsonism have been attributed to its catabolism to dopamine. Carbidopa, can markedly increase the proportion of levodopa that crosses the blood- brain barrier by
(A) increasing penetration of levodopa through BBB by complexation with it
(B) decreasing peripheral metabolism of levodopa
(C) decreasing metabolism of levodopa in the CNS
(D) decreasing clearance of levodopa from the CNS
Option B

Q.6 Ethambutol molecule has
(A) two chiral centers and 3 stereoisomers
(B) two chiral centers and 4 stereoisomers
(C) two chiral centers and 2 stereoisomers
(D) one chiral center and 2 stereoisomers
Option B

Q.7 A compound will be sensitive towards IR radiation only when one of the following properties undergo transition on
(A) Polarizability
(B) Dielectric constant
(C) Dipole moment
(D) Refractivity
Option C

Q.8 X-ray crystallographic analysis of an optically active compound determines its
(A) Optical rotatory dispersive power
(B) Absolute configuration
(C) Relative configuration
(D) Optical purity
Option B

Q.9 Which one of the following statements is wrong?
(A) A singlet or triplet state may result when one of the electrons from the HOMO is excited to higher energy levels
(B) In an excited singlet state, the spin of the electron in the higher energy orbital is paired with the electron in the ground state orbital
(C) Triplet excited state is more stable than the singlet excited state
(D) When the electron from the singlet excited state returns to ground state, the molecule always shows fluorescence phenomenon
Option C

Q.10 Aminotransferases usually require the following for their activity:
(A) Niacinamide
(B) Vitamin B12
(C) Pyridoxal phosphate
(D) Thiamine
Option C

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